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Have you ever wondered why twins, even though they have EXACTLY the same DNA, end up being so different? Not only personality-wise, they can also end up having completely different health conditions. Genes define us. They do, but to a certain extent. Behavior and environment also play a role in our development. And they can do so by causing genetic changes. But here's the thing: this does not necessarily involve any change in the DNA, but rather the way our body reads it. The study of these reversible changes is what we call epigenetics. Our lifestyle can trigger certain epigenetic changes. Some lifestyle factors linked to epigenetics include diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress, and working on night shifts. So, if a person's experiences can have an impact on their genome through epigenetics, does this mean it can all, somehow, be passed down to the offspring? Well, not really. Although epigenetic changes can indeed be inherited. But it's not that simple. 00:00 Genes vs. environment 00:55 Twins. Why are they different? 02:10 The basics 03:10 Epigenetic mechanisms 04:08 Epigenetics and lifestyle 06:23 Dutch Hunger Winter 07:50 Inheritance of epigenetics SOURCES: A systematic review of smoking-related epigenetic alterations https://pubmed.ncbi.nlm.nih.gov/31555... The role of cigarette smoke-induced epigenetic alterations in inflammation https://epigeneticsandchromatin.biome... Super interesting Review that I said I would link (Epigenetics and lifestyle) https://www.ncbi.nlm.nih.gov/pmc/arti... Epigenetics & Inheritance https://learn.genetics.utah.edu/conte... Environmental Influences on Gene Expression https://www.nature.com/scitable/topic.... Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline https://www.frontiersin.org/articles/... RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment https://www.cell.com/cell-reports/ful... Epigenetic differences arise during the lifetime of monozygotic twins https://www.ncbi.nlm.nih.gov/pmc/arti... The Famine Ended 70 Years Ago, but Dutch Genes Still Bear Scars https://www.nytimes.com/2018/01/31/sc... DNA methylation signatures link prenatal famine exposure to growth and metabolism https://www.nature.com/articles/ncomm... Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons https://www.nature.com/articles/s4146... You can find me here: Instagram: / dnandrea.science Twitter: / dnandreascience Email: dnandreacontacto@gmail.com Tiktok: tiktok.com/dnandrea.science See you next time :)