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This webinar was presented at 30 March 2022 by Dr. Mariangela Mancini, surgeon in the urological clinic at the University Hospital of Padua in Italy. It is aimed at both healthcare professionals and patient organisations. Etiology, incontinence score, fistula size, and timing of surgery are not correlated with successful repair, although size is strictly associated with the length of the fistulous tract. The abdominal approach allows definitive cure even in the most challenging cases, when bladder reconstruction is necessary. An extraperitoneal transvesical approach is safe and successful in the majority of cases. Maximal results can be expected in centres of experience at the first attempt on a previously non-treated patient. Minimally invasive techniques, such as laparoscopy or robotic surgery, can reduce the invasiveness of the open approach, when properly performed. Standardization of surgical key points based on experience and centralization of care in referral centres, connected in international networks of expertise, are the keys to success. eUROGEN is the European Reference Network for rare and complex urogenital diseases and conditions. Our multidisciplinary teams of experts are able to diagnose, suggest treatment or surgery, and then provide post-operative and transitional support. We have full members and affiliated partners across the majority of EU Member States. For more information or to contact us: Web: www.eurogen-ern.eu Email: [email protected] LinkedIn: / ern-eurogen Twitter/Instagram: @ERN_eUROGEN Facebook: / erneurogen YouTube: https://bit.ly/eUROGENyoutube