Med Review: Prescribing in Practice: Safety, Monitoring, and Drug-Drug Interactions For Resmetirom скачать в хорошем качестве

Med Review: Prescribing in Practice: Safety, Monitoring, and Drug-Drug Interactions For Resmetirom

In this educational video, Andrew Garza, MPAS, PA-C, provides a comprehensive clinical overview of safety monitoring, adverse events, and drug–drug interactions associated with Resmetirom, the first FDA-approved therapy for metabolic dysfunction–associated steatohepatitis (MASH) with F2–F3 fibrosis. Drawing from both clinical experience and data from the MAESTRO-NASH trial, Andrew reviews the most common side effects observed with resmetirom, including diarrhea, nausea, pruritus, vomiting, constipation, abdominal pain, and dizziness. He explains that gastrointestinal symptoms—particularly diarrhea and nausea—are the most frequent causes of discontinuation, though they are typically mild, self-limited, and most common within the first 12 weeks of therapy. The discussion also covers transient liver enzyme elevations, rare hepatotoxicity considerations, and recommended liver function monitoring intervals at 3, 6, and 12 months. In addition, this video outlines clinically important drug interactions, including CYP2C8 and OATP1B1/1B3 inhibitors (such as gemfibrozil, cyclosporine, and clopidogrel), weight-based dosing adjustments, and maximum statin dose recommendations when co-administered with resmetirom. This practical, evidence-based review is essential for endocrinology, hepatology, and primary care providers managing patients with MASH and advanced fibrosis who are initiating resmetirom therapy.