Keynote Presentation: Applying Nanovial Technology to Discover Rare T Cell Receptors with Live Q&A скачать в хорошем качестве

Keynote Presentation: Applying Nanovial Technology to Discover Rare T Cell Receptors with Live Q&A

Presented By: Dino Di Carlo, Ph.D. Speaker Biography: Dino Di Carlo is the Armond and Elena Hairapetian Professor of Bioengineering at UCLA, serial entrepreneur and inventor. He serves in academic leadership roles as the Vice Chair of the Bioengineering Department and Deputy Director of a National Science Foundation Engineering Research Center. He is an author on 190 peer-reviewed articles and an inventor on 75 issued patents in the U.S. and across the world. He has received numerous awards, including the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor bestowed upon young scientists and engineers in the U.S. He also has served in business leadership roles. He co-founded seven startup companies in life science research tools, diagnostics, medical device, and pharmaceutical industries over the last 10 years and continues to serve on the board of directors of many of these companies. He is a co-founder and director at Cytovale, a 100+ person company commercializing an FDA-cleared sepsis diagnostic test for rapid triage in the emergency department. Webinar: Keynote Presentation: Applying Nanovial Technology to Discover Rare T Cell Receptors with Live Q&A Webinar Abstract: Nanovials are emerging as an accessible platform for performing single-cell functional screening leveraging standard instrumentation, such as flow cytometers and microfluidic single-cell sequencing platforms. Each cell and its secreted products are captured in nanovials where they can be analyzed and sorted using widely available fluorescence activated cell sorters. I will first touch on previously demonstrated applications of using the nanovial platform to discover monoclonal antibodies and focus discussion on our recent work using nanovials for the selection of T cells based on their secretion of cytokines and downstream sequencing of T cell receptors (TCRs). Nanovials enable selective binding, functional characterization of secretion of cytokines and other effector molecules, followed by sorting of T cells for downstream sequencing of T cell receptor (TCR) alpha and beta chains, with functional annotation. Because both binding and cellular function can be assayed for millions of cells with standard equipment, this new "lab on a particle" approach can accelerate the discovery of monoclonal antibodies, cancer-specific TCRs, and TCRs against metabolites presented by unconventional major histocompatibility complex (MHC)-like molecules, with high accuracy, promising to transform the discovery of therapeutic antibodies and critical recognition elements for improved T cell therapies. Earn PACE Credits: 1. Make sure you’re a registered member of Labroots (https://www.labroots.com/) 2. Watch the webinar on YouTube or on the Labroots Website (https://www.labroots.com/ms/webinar/k...) 3. Click Here to get your PACE credits (Expiration date – March 20, 2026): (https://www.labroots.com/credit/pace-... Labroots on Social: Facebook:   / labrootsinc   Twitter:   / labroots   LinkedIn:   / labroots   Instagram:   / labrootsinc   Pinterest:   / labroots   SnapChat: labroots_inc