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Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It is strongly associated with cirrhosis, from both alcohol and viral etiologies. HCC constitutes approximately 5% of all cancers partly due to the high endemic rates of hepatitis B infection. Variable appearance with ultrasound depending on the individual lesion, size, and echogenicity of background liver. Typically: small focal HCC appears hypoechoic compared with normal liver larger lesions are heterogeneous due to fibrosis, fatty change, necrosis and calcification a peripheral halo of hypoechogenicity may be seen with focal fatty sparing diffuse HCC may be difficult to identify or distinguish from background cirrhosis CONTRAST ENHANCED ULTRASOUND Arterial phase: arterial enhancement from neovascularity Portal venous phase decreased echogenicity relative to background liver ("wash out") tumour thrombus may be visible Variants have been described with arterial phase hypovascularity with no enhancement or arterial enhancement with no "washout"