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The purpose of PGS is to examine the genetic information of an embryo, to identify embryos that have the correct number of chromosomes. Choosing to implant only embryos with the correct number of chromosomes may help to increase the chance for implantation, and reduce the chance for miscarriage. PGS does not screen for single gene conditions like cystic fibrosis, or muscular dystrophy. Chromosomes are bundles of tightly coiled DNA located inside almost every cell in the body. Humans have 23 pairs of chromosomes numbered 1 to 22, plus the sex chromosomes. Females have two X chromosomes, and males have one x, and one Y chromosome. Embryos can have missing or extra copies of their chromosomes, and the chance for these changes increases with maternal age. An example of a chromosome change is Down syndrome, also known as trisomy 21, which signifies that three copies of chromosome 21 are present, rather than the two copies that are normally present. PGS can be performed for several different reasons including advanced maternal age, multiple unsuccessful cycles of in vitro fertilization (IVF), recurrent pregnancy loss, a prior pregnancy with a chromosome abnormality, or patient choice. In order to do PGS testing IVF must first be performed. Once embryos have formed a skilled embryologist will them grow them in culture. On day five of an embryo’s development there are two different populations of cells. Cells that would form the fetus, and cells that would contribute to the embryonic part of the placenta. An embryologist uses a small tool on the fifth or sixth day to remove a few cells, usually three to five, from the population that will form the placenta. This is called a biopsy. There is evidence that most of the time the placental cells are almost identical to the cells that will develop into the fetus. Cells that will form any part of the fetus are not removed during PGS. There is a chance that the cells removed during PGS do not completely represent the genetic information of a future pregnancy itself. A PGS normal embryo does not guarantee a healthy pregnancy. A genetic counselor can help you understand the results of your PGS testing. PGS is still considered experimental by the American Society of Reproductive Medicine and is not considered a national standard of care. Learn more about the Center for Infertility and Reproductive Surgery at Brigham and Women’s Hospital: https://www.brighamandwomens.org/obgy...