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This educational webinar from the International Myeloma Foundation featured Dr. Beth Faiman (Cleveland Clinic) and Dr. Zainab Shahid (Memorial Sloan Kettering) discussing infection risks in multiple myeloma patients and prevention strategies. The presentation covered why myeloma patients face elevated infection risks, what types of infections to watch for, and comprehensive prevention approaches including vaccinations, prophylactic medications, and lifestyle measures. Key Points Why Myeloma Patients Are at Higher Risk: 5-7 times greater infection risk than general population Myeloma disrupts plasma cells that produce protective antibodies Highest risk during first months of treatment and later in disease progression (bimodal distribution) Treatment-induced low white blood cell counts increase vulnerability Risk Factors Beyond Myeloma: Comorbidities: diabetes, kidney disease, heart disease Low immunoglobulin levels (hypogammaglobulinemia) Specific treatments (CAR T-cell therapy, bispecific antibodies carry highest risk) Older age and immune system aging Prevention Strategies: Prophylactic medications: Acyclovir/valacyclovir (shingles prevention), Bactrim (PJP prophylaxis for CAR T/bispecific patients) Vaccinations: Seasonal flu, COVID-19, pneumococcal, RSV (age-appropriate), and shingles vaccines Post-CAR T revaccination: Starting at 6 months with multiple vaccines IVIG therapy: For patients with recurrent sinopulmonary infections and low IgG levels Basic precautions: Hand hygiene, masking in crowds/healthcare settings, avoiding sick contacts Treatment-Specific Guidance: Traditional therapies (lenalidomide, bortezomib): Lower risk, mainly shingles prevention needed Anti-CD38 antibodies: Moderate risk, watch for pneumonia and viral infections CAR T/bispecific antibodies: Highest risk, requiring comprehensive prophylaxis and close monitoring for 90+ days Key Message: Infection prevention should be individualized based on treatment phase, specific therapies, blood counts, and personal risk factors through ongoing discussion with healthcare providers. Download slides: https://www.myeloma.org/videos/living... _______________ Improving Lives | Finding the Cure Founded in 1990, the International Myeloma Foundation (IMF) is the first and largest organization focusing specifically on multiple myeloma. The IMF’s reach extends to more than 525,000 members in 140 countries worldwide. The IMF is dedicated to improving the quality of lives of myeloma patients while working toward prevention and a cure through our four founding principles: Research, Education, Support, and Advocacy. Subscribe to our channel: / imfmyeloma Visit our website at: https://www.myeloma.org Find us online: Facebook: @myeloma | / myeloma X/Twitter: @IMFMyeloma | / imfmyeloma Instagram: @imfmyeloma | / imfmyeloma LinkedIn: / international-myeloma-foundation Support the IMF | Donate Now! https://fundraise.myeloma.org/give/52... Category Nonprofits & Activism License Standard YouTube License The International Myeloma Foundation is committed to accessibility for all. That’s why all English-language videos uploaded to our YouTube channel feature human-transcribed closed captioning. This ensures more accurate captions for viewers who are Deaf or hard of hearing and improves the quality of automatic translations into other languages for our global audience.