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The Leonard Wolfson Experimental Neurology Centre (LWENC) research programme is coming to a close this year and we would like to invite you to join us in celebrating the achievements of the programme and the exceptional award from the Wolfson Foundation that made this all possible. The award has been transformational for translational research in neurodegenerative diseases at Queen Square. Many elements will continue on under different funders, a testament to its sustainability and ongoing success—for example, the LWENC CRF with NIHR support, the Fluid Biomarkers lab with DRI support, and the Training Programme under our new Wolfson-Eisai scheme. The symposium will feature talks from our key research areas and include keynotes from Professors Randall Bateman and Henrik Zetterberg. Full programme Pre-conference session – Final year student talks • Nick Wood and Elizabeth Halton 09:00 A computational approach to goal-directed behaviour in Huntington’s disease, Akshay Nair 09:15 A peripheral mechanism of cold allodynia in neuropathic pain, Donald Iain MacDonald 09:30 The stress granule response in wild-type and ALS-mutant mouse neurons, Matthew Bentham 09:45 Blood and CSF biomarkers for Alzheimer’s disease – from clinical to pre-clinical cohorts, Ashvini Keshavan 10:00 – 10:45 Networking and Refreshment Break Accelerating translation – Biomarkers, pathology and genetics • Martin Rossor and Nick Fox 10:45 Welcome and opening address, Mike Hanna 10:50 Overview of LWENC and introduction of keynote, Nick Fox 11:00 Keynote 1: Biomarkers and collaborations at UCL, Henrik Zetterberg 11:35 Pathology, validating PET tracers, Tammaryn Lashley 11:50 Genetics: progress and challenges, John Hardy 12:10 – 12:20 Comfort Break Cohorts • Helene Plun-Favreau and Selina Wray 12:20 Preclinical dementia – insights from a birth cohort, Jonathan Schott 12:35 Frontotemporal dementia: genetic cohorts to trials, Jonathan Rohrer 12:50 Epigenetics in Prion Diseases, Emmanuelle Vire 13:05 – 14:15 Lunch Education – Building Capacity • Linda Greensmith, Nick Wood and Elizabeth Halton 14:15 Educational vision and the student experience + Flash talks, Nick Wood and Elizabeth Halton, Student Alumni 15:00 – 15:30 Networking and Refreshment Break Novel therapies • Adrian Ivinson and Sarah Tabrizi 15:30 Clinical Research Facility: achievements and legacy, Vincenzo Libri 15:45 Genetic Therapies for Huntington’s disease, Sarah Tabrizi 16:05 Alzheimer’s disease and trials, Cath Mummery 16:20 Parkinson’s disease: hypothesis to bench to trial, Tony Schapira Keynote 2 • Cath Mummery 16:35 Introduction of keynote, Cath Mummery 16:40 Keynote 2: Prospects for prevention, Randy Bateman 17:15 Closing remarks, Alan Thompson 17:20 Prize presentations, Provost and Paul Ramsbottom 17:30 – 18:30 Drinks Reception #UCLDementiaSeminars Leonard Wolfson Experimental Neurology Centre (LWENC) https://www.ucl.ac.uk/ion/research/ce...