The Wnt pathway in a normal and in a tumour cell HD скачать в хорошем качестве

The Wnt pathway in a normal and in a tumour cell HD

In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein beta-catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of beta-catenin in the cytosol and also in the nucleus is increased. Nuclear beta-catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of beta-catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis. #onkoview, #myc, #wnt, #tumor, #cell, #beta-catenin, #oncogenes, #genes