Breakthrough in Methyltransferase Assays: Using the AptaFluor SAH Assay for HTS скачать в хорошем качестве

Breakthrough in Methyltransferase Assays: Using the AptaFluor SAH Assay for HTS

Methyltransferases are critical epigenetic "writers" and high-value drug targets, especially in cancer research. But developing high-throughput screening (HTS) assays for these enzymes has been a longstanding challenge—until now. In this video, we introduce the AptaFluor® SAH Assay by BellBrook Labs: a next-generation solution for detecting methyltransferase activity with unmatched sensitivity and specificity. Leveraging the natural selectivity of RNA aptamers, our team developed a TR-FRET-based, homogeneous assay capable of detecting low nanomolar SAH in the presence of excess SAM—meeting the stringent requirements of even the slowest MT enzymes. ✅ Detects SAH, the universal product of SAM-dependent methylation ✅ Enables HTS and accurate IC₅₀ determination for protein, nucleic acid, and small molecule MTs ✅ Works at SAM concentrations as low as 100 nM ✅ Outperforms all other HTS-compatible methyltransferase assays Learn how BellBrook’s innovative riboswitch-based technology unlocks the full potential of methyltransferase drug discovery. 🔬 For more on AptaFluor technology: https://bellbrooklabs.com/products/as... 📧 Contact us to request a free assay evaluation: info@bellbrooklabs.com #Epigenetics #Methyltransferase #HTS #DrugDiscovery #BellBrookLabs #AptaFluor #SAHAssay #EnzymeAssays #EpigeneticDrugDiscovery