The Nobel Prize in Physiology or Medicine 2019 скачать в хорошем качестве

The Nobel Prize in Physiology or Medicine 2019

The 2019 Nobel Prize in Physiology or Medicine has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.” Animals need oxygen for the conversion of food into useful energy. The fundamental importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown. This year’s Nobel Prize awarded work reveals the molecular mechanisms that underlie how cells adapt to variations in oxygen supply. 2019 Medicine Laureates William G. Kaelin Jr, Sir Peter J. Ratcliffe, and Gregg L. Semenza have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen. When oxygen levels are low (hypoxia), HIF-1α is protected from degradation and accumulates in the nucleus, where it associates with ARNT and binds to specific DNA sequences (HRE) in hypoxia-regulated genes At normal oxygen levels, HIF-1α is rapidly degraded by the proteasome, Oxygen regulates the degradation process by the addition of hydroxyl groups (OH) to HIF-1α The VHL protein can then recognize and form a complex with HIF-1α leading to its degradation in an oxygen-dependent manner The seminal discoveries by this year’s Nobel Laureates revealed the mechanism for one of life’s most essential adaptive processes. They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function. Oxygen sensing is central to a large number of diseases. The discoveries have fundamental importance for physiology and have paved the way for promising new strategies to fight anemia, cancer and many other diseases. http://bit.ly/2Vmq6iQ #NobelPrize #Physiology #Medicine ❤ If you find our videos helpful, become a channel member http://bit.ly/SubscribeResearchStash For the latest Science, Tech news and conversations, follow Research Stash on Twitter, Facebook, and subscribe to our YouTube channel https://www.researchstash.com/   / researchstash     / researchstash      / researchstash   📩 For any queries/collaboration etc, please contact us from here https://www.researchstash.com/contact... OR Email us at hello@researchstash.com