5 Species Liver Chip to assess cross species drug toxicity and human relevance скачать в хорошем качестве

5 Species Liver Chip to assess cross species drug toxicity and human relevance

Author: Kyung-Jin Jang (Emulate) Summary: Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. In this presentation, we introduce our microengineered Liver-Chip technology to design a dog and human Liver-Chip containing species- specific primary hepatocytes interfaced with liver sinusoidal endothelial cells, Kupffer cells and hepatic stellate cells, cultured under physiological fluid flow. The Liver-Chip detected diverse phenotypes of liver toxicity, including hepatocellular injury and cholestasis, and species-specific toxicities when treated with tool compounds. A species Liver-Chip may provide a useful platform for prediction of liver toxicity and inform human relevance of liver toxicities to better determine safety and human risk.