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Used alone or in concert with other assessments like EEG, noninvasive microdialysis is a powerful technique to support drug development. In this video, in vivo pharmacologist Dr. Holden Janssens describes how Charles River uses microdialysis to measure free compound levels in blood, organs like the brain, gut, liver, lung, and heart, and even within tumors. Performed in awake animals, these assessments employ highly technical skill to place microdialysis probes into a specific area of target tissue to deliver and sample compound analytes and native proteins (such as neurotransmitters) to determine effects and measure change. Charles River offers a range of microdialysis services to support your drug development. Learn more here: https://bit.ly/2XwhisK For over 70 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. https://bit.ly/2RTdGOU