The Nobel Prize in medicine goes to 3 scientists for work on the human immune system скачать в хорошем качестве

The Nobel Prize in medicine goes to 3 scientists for work on the human immune system

(6 Oct 2025) RESTRICTION SUMMARY ASSOCIATED PRESS Stockholm - 06 October 2025 1. Various of Nobel Forum in Stockholm 2. Members of Nobel Assembly arriving 3. Photographs of winners of 2025 Nobel Prize in Physiology or Medicine on screen behind panel 5. SOUNDBITE (English) Marie Wahren-Herlenius, Karolinska Institute rheumatology professor: "This year's Nobel Prize in Physiology or Medicine relates to how we keep our immune system under control so we can fight all imaginable microbes and still avoid autoimmune disease." 6. Pan of photographs of winners on screen behind panel 7. Screen showing presentation of winners' work 8. Chair of the Nobel Committee Olle Kämpe talking to journalists 9. SOUNDBITE (English) Olle Kämpe, Chair of the Nobel Committee: "This year Nobel laureates, what they discovered was a principle, how we avoid self-reactivity and thus how we avoid autoimmune diseases. So they discovered a cell type which is less than 10% of all T-cells that has this specific ability to tell other T-cells to stop if they attack our own body." 10. Members of Nobel Assembly 11. Nobel medal sign on lectern 12. SOUNDBITE (English) Olle Kämpe, Chair of the Nobel Committee: "The medical implications is perhaps 10 years from now. There are a lot of studies going on but they're very early studies and that's to treat autoimmunity but also to avoid transplantation rejection and then as a treatment for cancer because many tumors they surround themselves with T-regulatory cells to avoid our own immune system to attack the cancer." 13. Various of Nobel statue on display STORYLINE: Mary E. Brunkow, Fred Ramsdell and Dr. Shimon Sakaguchi won the Nobel Prize in medicine on Monday for their discoveries concerning peripheral immune tolerance. Brunkow, 64, is a senior program manager at the Institute for Systems Biology in Seattle. Ramsdell, 64, is a scientific adviser for Sonoma Biotherapeutics in San Francisco. Sakaguchi, 74, is a distinguished professor at the Immunology Frontier Research Center at Osaka University in Japan. The immune system has many overlapping systems to detect and fight bacteria, viruses and other bad actors. Key immune warriors such as T cells get trained on how to spot bad actors. If some instead go awry in a way that might trigger autoimmune diseases, they’re supposed to be eliminated in the thymus — a process called central tolerance. The Nobel winners unraveled an additional way the body keeps the system in check. The Nobel Committee said it started with Sakaguchi’s discovery in 1995 of a previously unknown T cell subtype now known as regulatory T cells or T-regs. Then in 2001, Brunkow and Ramsdell discovered a culprit mutation in a gene named Foxp3, a gene that also plays a role in a rare human autoimmune disease. The Nobel Committee said two years later, Sakaguchi linked the discoveries to show that the Foxp3 gene controls the development of those T-regs — which in turn act as a security guard to find and curb other forms of T cells that overreact. The work opened a new field of immunology, said Karolinska Institute rheumatology professor Marie Wahren-Herlenius. Researchers around the world now are working to use regulatory T cells to develop treatments for autoimmune diseases and cancer. The medical implications is perhaps 10 years from now," said Olle Kämpe, chair of the Nobel Committee. The award is the first of the 2025 Nobel Prize announcements and was announced by a panel at the Karolinska Institute in Stockholm. The trio will share the prize money of 11 million Swedish kronor (nearly $1.2 million). Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter:   / ap_archive   Facebook:   / aparchives   ​​ Instagram:   / apnews   You can license this story through AP Archive: http://www.aparchive.com/metadata/you...