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Do you have questions about the effect of testosterone on psa or your prostate specific antigen? Do you want to know whether or not testosterone therapy is going to make your psa go up and if so why is that happening should you be worried. In this video we're going to answer that specific question does testosterone affect your psa we're going to address why this happens and what to expect when you're on testosterone replacement therapy and your psa. **WORK WITH ME ⭐️ : https://www.swintegrativemedicine.com... **EBOOK ** Mastering Your TRT: A Guide to Thriving on Testosterone. https://discover-holistic-health-acad... https://academic.oup.com/jcem/article... so this video is going to answer the question does testosterone affect psa and this comes from a specific question i got from a viewer they were asking do high levels of testosterone from testosterone cpn affect your psa levels so the answer to this question is yes testosterone almost always raises psa given enough time testosterone increases the body's production of two important hormones that have an effect on prostate tissue and those are estradiol and dihydrotestosterone also known as dht both of these hormones can cause the prostate cells to individual cells to grow and then divide and turn into new prostate cells since psa is a protein psa stands for prostate specific antigen an antigen is a protein since it is a protein and the amount of that protein is a reflection of the amount of prostate tissue available or present it only makes sense that more prostate tissue means higher psa we also know that with age the psa and prostate size generally does increase and in part that's thought to be a reflection of the prostate tissues exposure to these hormones testosterone dht estradiol while there are some small studies showing that tsa does not rise upon administering testosterone there are plenty of studies that are more well designed that do show psa going up upon initiating testosterone therapy you do have to give it enough time because it's not going to happen after one shot or one month of application in some cases it can but it's over time those hormones have an effect on the prostate tissue also if you're applying testosterone topically and it's not actually getting into your body absorbing which is a common problem with topical then you may not have any effect because it's not actually changing those hormone levels in my practice i commonly do see increased tsa levels when people start testosterone replacement therapy there's usually an initial spike after a few months of being on it and then it kind of stabilizes and then you sort of fall into the normal trajectory for age it might might rise over a couple two three years again after that so it's typically going to stabilize after the initial rise in psa when you start the testosterone replacement therapy then you know there's a whole question about does psa even matter what is the value of doing the test that's not really what this video is about but if you do have questions about things like that or other questions about testosterone in psa rising.