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Watch the Full Video at https://www.jove.com/v/50991/a-compre.... A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures - a 2 minute Preview of the Experimental Protocol Matthew Moore, Yifan Hu, Sarah Woo, Dylan O'Hearn, Alexandru D. Iordan, Sanda Dolcos, Florin Dolcos University of Illinois Urbana-Champaign, Psychology Department; University of Illinois Urbana-Champaign, Neuroscience Program; University of Illinois Urbana-Champaign, Beckman Institute for Advanced Science and Technology; The present work provides a comprehensive set of guidelines for manually tracing the medial temporal lobe (MTL) structures. This protocol can be applied to research involving structural and/or combined structural-functional magnetic resonance imaging (MRI) investigations of the MTL, in both healthy and clinical groups. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments