GENFIT - Acute-on-Chronic Liver Failure (ACLF) Highlights скачать в хорошем качестве

GENFIT - Acute-on-Chronic Liver Failure (ACLF) Highlights

This video introduces ACLF, the disease progression and the associated multiple organ failure. It also presents GENFIT's unique pipeline with 5 assets in ACLF. Sources: “23% to 74% of mortality at 28 days” Arroyo V et al., Nat. Rev. Dis. Primers 2 (2016) “US: $52,000 per hospitalization per patient” Kamath 2017 “The in-ICU mortality rate was 49.3%.” 50% 1 out of 2 Pereira R, Bagulho L, Cardoso FS. Acute-on-chronic liver failure syndrome - clinical results from an intensive care unit in a liver transplant center. Rev Bras Ter Intensiva. 2020 Mar;32(1):49-57. doi: 10.5935/0103-507x.20200009. Epub 2020 May 8. PMID: 32401978; PMCID: PMC7206960. “Numbers of organ failures affected” Moreau R et al, Gastroenterology 2013 Trebicka J et al, Visceral Medicine 2018 EASL-Clinical Practice Guideline on Decompensated Cirrhosis 2018 Mezzano G et al, Gut 2022 Lee BP et al, J Hep 2022 “Probability of survival – Chart" Gustot T, et al. Hepatol 2015. Arroyo V, et al. NEJM 2020. All drugs under development are investigational compounds that have not been reviewed nor been approved by a regulatory authority in targeted indications