Pankaj Kapahi on Rapamycin Longevity Series | There is no one size intervention that fits all скачать в хорошем качестве

Pankaj Kapahi on Rapamycin Longevity Series | There is no one size intervention that fits all

Professor Pankaj Kapahi has his own lab at the Buck Institute for Research on Aging. His research for two decades has been focusing on things such as dietary restriction, fasting, rapamycin, nutrition and longevity. Pankaj was one of the pioneer researchers who discovered in the beginning of 2000 that genetic inhibition of mTOR led to life extension in flies. In this podcast we are going to talk about that discovery, Rapamycin, calorie restriction and other interesting longevity topics. 00:00 Intro 01:45 Pankaj's longevity interest and calorie restriction 03:05 How Pankaj's longevity research started 04:54 Activating the survival defense mode 06:38 The survival mode is a stress response 08:10 Difference between calorie and dietary restriction 09:22 Limiting calories preserves muscle mass 10:47 Biomarkers when guide us to avoid overdoing things 13:27 Genetic mTOR inhibition discovery in flies 16:29 Protein restriction as mTOR inhibitor 17:28 Is it possible to genetically inhibit mTOR late in life 18:34 Rapamycin vs genetic inhibition of mTOR 20:36 Weak points regarding Rapamycin 25:13 Pankaj's Rapamycin usage 26:58 Daily vs weekly dosing 29:48 Side effects Pankaj has experienced with Rapamycin 29:51 Pankaj's beneficial effects with Rapamycin 31:56 Pankaj's risk and benefit calculation 34:15 Additives to Rapamycin 36:52 Fasting vs calorie restriction 39:01 GLYLO and Advanced Glycation End products (AGEs) 41:06 Combining Rapamycin and GLYLO 42:47 How GLYLO was discovered 46:31 Why don't more people talk about AGEs 48:25 Diseases related to AGEs 51:30 ITP proposal to test GLYLO 53:03 Rapamycin + GLYLO vs Rapamycin + Acarbose 54:00 GLYLO is sold as a supplement 54:14 Pankaj's dose regime of GLYLO 54:27 How Pankaj combine GLYLO and Rapamycin 55:22 Side effects Pankaj has experienced with GLYLO 56:29 Pankaj's beneficial effects with GLYLO 57:52 Alternatives to reduce AGEs 1:02:19 Rapamycin and it's effects on AGEs 1:03:48 What is the best dose regime of Rapamycin for longevity? 1:04:58 How well will Rapamycin work in humans? 1:06:09 Any additive effect with combining extended fasting with Rapamycin? Links Kapahi's Lab at Buck Institute https://www.buckinstitute.org/lab/kap... Juvify and GLYLO https://juvifyhealth.com Pankaj's twitter   / kapahi_pankaj   Rapamycin resources Rapamycin Longevity Lab https://masteronething.com Rapamycin.news https://www.rapamycin.news Rapamycin Facebook group   / rapamycin   Rapamycin Reddit group   / rapamycin   Connect with Krister on: Twitter:   / kristerkauppi   Instagram:   / longevity.lifestyle.hacker   Disclaimer: The podcast is for general information and educational purposes only and is not medical advice for you or others. The use of information and materials linked to the podcast is at the users own risk. Always consult your physician with anything you do regarding your health or medical condition.