Solitary Fibrous Tumors: Research Advances, Treatment Strategies, and Hope for Sarcoma Patients скачать в хорошем качестве

Solitary Fibrous Tumors: Research Advances, Treatment Strategies, and Hope for Sarcoma Patients

How are breakthroughs in sarcoma research offering new hope for solitary fibrous tumor patients? Dr. Peter Crane interviews Dr. Javier Martin-Broto on his 30+ years in oncology, key trials with anti-angiogenics, and emerging therapies like alternative splicing inhibitors. Vital for physicians, residents, and patients seeking insights on rare cancers and innovative care. ⏱️ Timestamps 00:00 – Introduction and Dr. Martin-Broto's background in oncology 01:00 – Journey into medical oncology and sarcoma focus since 1994 03:00 – Role of research in oncology: Preclinical, translational, and clinical trials 05:00 – First SFT clinical trial: Pazopanib cohorts and key messages on efficacy 07:00 – SFT classification shifts and metastatic behavior 09:00 – Anti-angiogenics vs. chemotherapy: Better PFS and rotation strategies 11:00 – Challenges with SFT subtypes and immunotherapy limitations 13:00 – Microenvironment's role and immune modulation potential 15:00 – Preclinical models: Organoids and testing new compounds 17:00 – Promising lines: BET inhibition and alternative splicing (tepotinib) 19:00 – Phase II trial updates: Tumor shrinkage observations 21:00 – Combined therapies: Trabectedin + radiation for bulky tumors 23:00 – Personalized testing via tumor disgrates 25:00 – Hopeful research directions and cytokine influence 27:00 – Clinical trial timelines and ESMO updates 29:00 – Strategies for inoperable masses and brain SFT 31:00 – Messages for patients: Advocacy, expert teams, and innovative access 33:00 – Closing thoughts and thanks 🔗 Resources Mentioned Spanish Sarcoma Group — GEIS Group ESMO Meeting — esmo.org 👍 If this episode helped you, please like, subscribe, and share — it helps these conversations reach the physicians who need them most. #DoctorsMakingADifference, #SolitaryFibrousTumor, #SarcomaResearch, #MedicalOncology, #RareCancers, #AntiAngiogenics, #CancerTrials, #PhysicianInnovation, #SarcomaCare, #TumorShrinkage, #PatientHope, #OncologyAdvances, #SarcomaAdvocacy, #CancerResearch, #PhysicianLife #doctorpodcastnetwork