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In this video: Dr. Sean Hashmi, MD, MS, FASN—board-certified Nephrologist and Obesity Medicine Specialist—provides a critical analysis of the landmark PURE trial that studied 135,000 people across 18 countries for 7.4 years. You'll discover why the headlines claiming "saturated fat is healthy" miss crucial context, how the study may actually reflect poverty as a risk factor rather than proving fat benefits, and why current dietary recommendations remain unchanged. Thanks for watching! ➤ Subscribe for evidence-based health updates: / @seanhashmimd ➤ Join 5,000+ getting my free newsletter: https://www.selfprinciple.org/newsletter ➤ Visit my website for more resources: https://www.selfprinciple.org *CHAPTERS:* 00:00 Introduction - PURE Trial Questions 00:22 Study Design: 18 Countries, 135K People 01:37 Primary & Secondary Outcomes 02:05 Study Adjustments & Methodology 02:31 Results: Fat vs Carbohydrate Findings 03:57 Critical Analysis: What's Missing 05:22 The Poverty vs Diet Question 06:02 Study Limitations & Funding Issues 07:18 Bottom Line: Current Recommendations *KEY INSIGHTS FROM THIS VIDEO:* • PURE trial: 135,000 people, 18 countries, 7.4-year follow-up • Higher fat intake = 33% lower all-cause mortality (but context matters) • Saturated fat = 14% lower mortality, 21% lower stroke risk • Higher carb intake = 20% higher mortality (36% non-cardiovascular) • Major flaw: No distinction between refined vs whole grain carbohydrates • High-carb consumers were mostly in poor countries eating refined grains • High-fat consumers were in wealthy countries with better healthcare access • "High fat" group actually consumed recommended amounts (≤30% total, ≤10% saturated) *SCIENTIFIC REFERENCES:* • PURE (Prospective Urban Rural Epidemiology) trial 2017 • 18 countries across 5 continents (high, medium, low income) • Validated food frequency questionnaires • Companion paper showing fruits/vegetables/legumes reduce disease risk *RELATED VIDEOS TO DEEPEN YOUR KNOWLEDGE:* • Scientific Approach to Nutrition 2018: [LINK] • Saturated Fat vs Heart Disease: What Science Shows: [LINK] *EXPLORE MY PLAYLISTS:* • Longevity & General Wellness: • Longevity & General Wellness • Kidney Health Essentials: • Kidney Health Essentials *CONNECT WITH DR. HASHMI:* • Website: https://www.selfprinciple.org • Instagram: @seanhashmimd • Facebook: @seanhashmimd • TikTok: @seanhashmimd ➤ Have a question about this video? Drop it in the comments – I read and respond to as many as I can! ➤ 💙 Help someone you care about: If you know someone confused by conflicting headlines about saturated fat and health, please share this video—critical analysis of studies helps everyone make better health decisions. *MEDICAL DISCLAIMER:* This content is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider for medical decisions, especially regarding dietary changes. Views expressed are Dr. Hashmi's alone and do not represent any employer or institution. Individual results may vary. Viewing does not establish a doctor-patient relationship. #PURETrial #SaturatedFat #NutritionScience #seanhashmimd #EvidenceBasedMedicine