Affinity | Ligand-Receptor Interactions || Junaid Asghar PhD скачать в хорошем качестве

Affinity | Ligand-Receptor Interactions || Junaid Asghar PhD

Receptors are macromolecules involved in chemical signaling between and within cells; they may be located on the cell surface membrane or within the cytoplasm. A drug’s ability to affect a given receptor is related to the drug’s affinity (probability of the drug occupying a receptor at any given instant) and intrinsic efficacy (intrinsic activity—degree to which a ligand activates receptors and leads to cellular response).A drug’s affinity and resultant activity are determined by its chemical structure. The pharmacologic effect of a drug is also determined by the duration of time that the drug-receptor complex persists (residence time). #Affinity #AgonistReceptorInteractions #Pharmacodynamics #JunaidAsgharPhD