Revumenib plus azacitidine and venetoclax in older adults with NPM1-mutated or KMT2A-rearranged AML скачать в хорошем качестве

Revumenib plus azacitidine and venetoclax in older adults with NPM1-mutated or KMT2A-rearranged AML

Joshua Zeidner, MD, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, discusses the safety and efficacy of azacitidine, venetoclax, and revumenib in newly diagnosed older adults with NPM1-mutated or KMT2A-rearranged acute myeloid leukemia (AML) in the Beat AML Master trial (NCT03013998). The study investigated two dose levels of revumenib, finding no non-hematologic dose-limiting toxicities (DLTs) and one hematologic DLT at the first dose level. Among all evaluable patients, there was a 100% overall response rate (ORR) and a 96% composite complete remission (CRc) rate. A Phase III trial for this combination is now being planned. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.