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Dr. Fabien Lareyre connects with Prof. Peter Schneider to discuss carotid disease, CLTI, and the dedicated carotid chapter of the yearly updated #pvi Trials Book, the essential reference to stay up to date with the latest and most influential studies. Prof. Schneider introduces the 2025 carotid chapter, highlighting trials on symptomatic and asymptomatic disease, emerging technologies, and cryptogenic stroke. He reflects on ACST-2 and a study linking dementia and cognitive decline to asymptomatic carotid stenosis, before pointing to CREST-2 as the trial most likely to reshape guidelines in 2026. The discussion also explores the role of AI in carotid disease, from imaging analysis to plaque research, and its potential to transform the field. Watch this exchange to discover why the PVI Trials Book is a must-have to keep pace with research and practice-changing evidence, and hurry up and download the 2025 edition while you wait for the new 2026 version (https://www.paris-vascular-insights.c...! #carotid, #clti, #cryptogenicstroke, #dementia, #cognitivedecline, #asymptomatic, #symptomatic, #stenosis, #ai, #imaging, #plaque