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HDL Is More Complicated Than High HDL-C Is Always Good I get a lot of questions about HDL in my practice and on social media I don’t try to duck the question, but want you to know it is way more complicated than you think High HDL-C is not necessarily a good thing Low HDL-C is not necessarily a bad thing The HDL-C measurement is almost useless at predicting risk It really comes down to HDL functionality and at this moment there are no good lab tests to assess that function Elevated myeloperoxidase (MPO) will oxidase the HDL particles and can be a marker of dysfunctional HDL You can check genetic markers: SCARB1 and the ATP Binding Cassette genes You can check Apo A1 levels and assess Apo B/Apo A1 ratios The Apo B side of the story is more important as that is what drives atherosclerosis risk so focus on this side of the lipids first Checking the health of your arteries with a CIMT, CT Coronary Calcium Score, or Cleerly CCTA is more useful than knowing if you have a normal “HDL” High-density lipoprotein (HDL) functionality and its relevance to atherosclerotic cardiovascular disease https://www.ncbi.nlm.nih.gov/pmc/arti... #hdl #hdl-c #hdl-p #lipid #apob #cad #atherosclerosis #MPO #myeloperoxidase