MEN1 Syndrome: Genetics, Mutations, Testing & Surveillance | Surgery PG Residency | Doctutorials скачать в хорошем качестве

MEN1 Syndrome: Genetics, Mutations, Testing & Surveillance | Surgery PG Residency | Doctutorials

MEN1 Syndrome is a genetic disorder linked to mutations in the menin gene on chromosome 11q13, which functions as a tumor suppressor in endocrine tissues. In this video, we explore the genetic mutations, including frame-shift, missense, and deletion mutations, and their impact on the development of various endocrine tumors like insulinomas, gastronomas, and VIPomas. We also cover the two-hit hypothesis of MEN1 mutation, screening guidelines for at-risk family members, and biochemical and radiological surveillance for MEN1-related tumors. Learn who should be genetically tested, the timing of biochemical screening, and the process of genetic counseling for first-degree relatives. Why Choose DocTutorials? DocTutorials provides expert-led content for PG residents, helping you deeply understand complex topics like MEN1 syndrome, genetics, and endocrine disorders. Our humanized approach to learning ensures that you can effectively prepare for exams and clinical practice. Get access to real-world solutions and in-depth exam strategies for Surgery and Endocrinology. 0:00 - Introduction to MEN1 Syndrome and the Menin Gene 0:06 - Genetic Overview: Location of MEN1 Gene (Chromosome 11q13) 0:10 - Functions of the Menin Protein 0:25 - Mutations in MEN1 Gene: Frameshift, Missense, Nonsense 1:35 - Two-Hit Hypothesis for MEN1 Syndrome 2:05 - MEN1 Syndrome and Endocrine Tumors: Insulinomas, VIPomas, and More 2:46 - Genetic Testing for MEN1: Who Should Be Tested? 3:46 - Surveillance Protocols for MEN1 Syndrome 4:18 - Clinical Diagnosis, Genetic Analysis, and Counseling for MEN1 4:35 - Biochemical Surveillance and Ongoing Monitoring 🔔 Subscribe to our channel for more detailed lectures on genetic syndromes, endocrine disorders, and essential Surgery PG topics. 📥 Download DocTutorials App for exclusive access to lectures, quizzes, and more. #MEN1Syndrome, #MEN1Genetics, #EndocrineTumors, #GeneticSyndromes, #MeninGene, #MEN1Mutation, #EndocrineDisorders, #Insulinomas, #SurgeryPG, #SurgeryResidency, #PGExamPrep, #DocTutorials, #GeneticTesting, #EndocrinePathology, #GeneticCounseling, #TumorSuppressor, #PGResidency, #MedicalEducation, #MedicalGenetics, #NEETPG, #MedicalTraining, #PGPrep, #Endocrinology, #ClinicalGenetics, #SurveillanceTesting, #MeninProtein, #GeneticMutations