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Patent Pulse: A Spotlight on Recent Highlights from Small Molecule Patents

Patents and patent applications often encapsulate the most sought-after chemical matter pursued by biotech and pharma companies. For medicinal chemists, monitoring the vast patent literature beyond your immediate targets can be daunting yet potentially transformative. A patent on a different target might describe some chemical matter or data that could significantly advance your project. It's easy to overlook innovations or new targets among the deluge of patents published each week. In this Coffee Chat, our team (Lew Pennington, Matt Hesse, and Dennis Koester), explores Drug Hunter’s patent highlight feature. They also share their favorite molecules and notable stories from recent patent filings. 0:00 Introduction and Welcome 2:38 Overview of Drug Hunter 6:17 Patent Search Tool and Team Introduction 8:58 PTPN1/2: Traditionally Difficult to Drug Target Sees Recent M&A Activity 12:02 SARM1: Competition in Challenging Neurodegenerative Disease Target is Heating Up 16:07 KARS inhibitors: An Interesting Cancer-Selective Product Takes Center Stage 20:44 IL-17A inhibitors: From Macrocycles to Small-Molecule Inhibitors 24:54 DHX9 inhibitors: A Novel Target in the Area of MSI High Cancers 28:23 LpxC inhibitors: Non-Hydroxamates Antibiotics with Potentially Superior Cardiosafety Profile 31:36 GLP-1R agonists: Recent Entries to a Highly Competitive Field 37:56 VAV1: Exploiting Non-Canonical Degrons with Systematically Discovered Molecular Glue Degraders 45:00 Q&A and Closing Remarks Recorded on October 18, 2024, as a Drug Hunter Coffee Chat. Sign up to be notified of future sessions here: https://drughunter.com/flash-talk-ser... Sign up for our free newsletter here: https://drughunter.com/newsletter-sig...