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Image guidance is an important adjunct for endoscopic sinus and skull base surgery. However, current systems require bulky external tracking equipment, and their use can interrupt efficient surgical workflow. In this study, a novel simultaneous localization and mapping algorithm–based approach to surgical navigation is evaluated in the anterior skull base. The system localizes anatomy in real time from 3-dimensional endoscopic images without requiring an external tracking system. This video demonstrates stereoscopic surface reconstruction and augmented endoscopy of the anterior skull base. A, With a brief pan of a 3-dimensional endoscope, a high-resolution 3-dimensional surface model of the operative field is created in real time from the surgeon’s perspective (demonstrated here in the posterior wall of a cadaveric sphenoid sinus). B, The surface model is registered to volumetric models segmented from preoperative patient imaging, thereby providing information about the relationship between the exposed tissue surface and underlying anatomic structures, allowing the surgeon to see through opaque tissue. Here, surgical navigation using augmented endoscopy is demonstrated with continuous localization of segmented anatomic structures from computed tomography (internal carotid arteries and optic nerves) as the endoscope is tracked in real-time with respect to the reconstructed surface using video-based features. Click https://ja.ma/3OPwX1i full details.