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Arthroscopic repair of risk factors and regenerative therapies delay the progression of Knee Osteoarthritis. Osteoarthritis (OA) is causing of pain and disability and leads to a reduced quality of life. Increasing age, obesity, occupational activities and knee injuries are the main risk factor for knee OA. Some of these risk factors can be modified at an individual patient level in order to minimize the risk of developing OA and therefore lead to an increased quality of life for patients. Various surgical methods are available for the treatment of articular cartilage and meniscal injury, anterior cruciate rupture etc. Articular cartilage (AC) injury is a major risk factor for the development of OA, an irreversible condition. Due to the limited capacity of AC to repair, early intervention is required to prevent progression to OA. Current treatment modalities aim to restore AC through primary repair, stimulation of adjacent tissue and graft implantation. Rigid fixation of osteochondral fractures in an acute setting. Microfracture and subchondral drilling breach subchondral bone to allow migration of cells and chemical mediators into defects. Although this leads to defect filling with repair tissue that is predominantly fibrocartilage, reasonable results can be obtained in the short- to intermediate-term with proper rehabilitation. Osteochondral autologous transplantation and mosaicplasty are performed through transplanting one or more osteochondral autografts from healthy, non-weight-bearing surfaces. Allogeneic transplantation is an alternative strategy for large osteochondral defects. The incidence of knee osteoarthritis (OA) increases to between approximately 15% and 20% after an Anterior Cruciate Ligament (ACL) tear, which represents a ten-fold increase. It is suggested that more than 50% of patients that sustain an ACL injury will develop symptomatic OA in the following 10 to 20 years. Despite the frequency in development of OA post-ACL injury, one of the main issues is whether ACL reconstruction can minimize the risk of ΟΑ progression. Instead, non-operative treatment resulted in poor and fair functional outcome scores that prevented a return to pre-injury activities in the majority of patients, as well as an increased incidence of secondary ACL and meniscus surgery. As a result, the more favourable outcome of ACL reconstruction establishes surgery as the first-line treatment for ACL-deficient knees in active patients. The menisci play also a critical role in normal knee function by providing important load bearing capabilities, lubrication, proprioception, joint congruity, and joint stability. Meniscal tears are common injuries, and while partial meniscectomy is a frequent treatment option, general meniscus loss is a risk factor for the development of osteoarthritis. Meniscal injury is associated with pain and degradative changes in the knee joint that may ultimately lead to osteoarthritis. Furthermore, the surgical treatment of a meniscal tear by partial or total meniscectomy is strongly associated with articular cartilage degradation and the progression of osteoarthritis. Therefore, surgeons attempt to preserve and repair the native meniscal tissue following injury. However, when repair is not feasible, partial meniscectomy is frequently implemented to treat meniscal tears. While these patients report improvements in pain and function, the ability of this surgery to mitigate the risk of premature development of osteoarthritis may be limited. Ιn terms of degenerative meniscus injuries it is best to treat them conservatively at first. Arthroscopic surgery in the middle aged and older population with knee pain represents most arthroscopies and is routinely performed on the basis of a suspected meniscal tear by clinical examination or as diagnosed by MRI, but usually middle aged patients with knee pain and meniscal tears should be considered as having early stage osteoarthritis and be treated for knee osteoarthritis, starting with activity modification, exercise, medication, physical therapy, intra-articular injection and often weight loss. Indeed, recent literature suggests that conservative treatment of degenerative meniscus injuries has the same long-term effects as surgery, but we insist on choosing partial meniscectomy when the symptoms persist despite 3-month treatment, especially in patients with a clear history of trauma or presentation of mechanical symptoms . In conclusion, the widespread dissemination and application of minimally invasive surgery and regenerative medicine now provides the opportunity to address the risk factors for delaying or inhibiting OA.