Super Babies & Revolutionizing Reproduction with Orchid's Noor Siddiqui: Full-Genome Embryonic Tests скачать в хорошем качестве

Super Babies & Revolutionizing Reproduction with Orchid's Noor Siddiqui: Full-Genome Embryonic Tests

In this episode of Harper Carroll AI, we chat with Noor Siddiqui, founder and CEO of Orchid, a biotech company revolutionizing reproductive technology through full-genome embryo screening. Noor shares her personal journey that led to the founding of Orchid and discusses the startup's mission to help families have healthier babies by screening for over 1,200 genetic conditions. The conversation goes into the science and AI advancements behind genetic sequencing, the ethical considerations, "super babies," and the groundbreaking impact this technology is having on families worldwide. They also discuss future visions for the technology to become more accessible and prevalent, ultimately transforming the approach to reproductive health. Orchid in the News: New Yorker, April 21, 2025: https://www.newyorker.com/magazine/20... New York Times, April 1, 2025: https://www.nytimes.com/interactive/2... Notes: "Calico cats are always female" - While most calico cats are female, rare exceptions exist, including male cats with XXY chromosomes (Klinefelter syndrome) or with genetic chimerism. "A person starting with 9 million eggs at embryo stage, 1 million at birth, and 400,000 at puberty" - These numbers are approximations. The most current research suggests female fetuses have about 6-7 million eggs at 20 weeks gestation, 1-2 million at birth, and about 300,000-500,000 at puberty. "Older women can carry children" - While presented as if there are no age-related limitations to pregnancy beyond egg quality, advanced maternal age is associated with increased pregnancy complications including gestational diabetes, preeclampsia, and placental issues. 00:00 Introduction 02:17 Noor Siddiqui's Personal Journey 04:27 Understanding IVF and Genetic Testing 07:56 The Science Behind Genetic Mutations 10:48 AI in Genomics: Data and Disease Correlation 21:25 Genetic Risk Scores and Model Validation 33:16 Embryo Genetic Testing 33:57 Genetic Testing Normalization 36:01 Genetic Lottery and Unfairness 36:50 Importance of Genetic Information 38:03 Top Genetic Conditions to Test For 39:09 Birth Defects and Hereditary Cancers 40:17 Genetic Risk Scores and Disease Thresholds 45:31 Harper's IVF / Egg Freezing Stories 49:29 The Miracle of Pregnancy 50:41 Future of Genetic Testing and Accessibility 53:58 Impact of Genetic Testing on Fertility 01:02:07 Orchid's Global Reach and Future 01:07:59 Conclusion and Final Thoughts #Podcast #ArtificialIntelligence #Interview