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You ever see that septic patient sitting on 3 pressors at a heart rate of 150, and think "I wonder if they would benefit from increased diastolic filling?" When we decide to decrease a patient's heart rate, we are directly dropping the rate in hopes that we will indirectly increase cardiac output. Sometimes that happens and other times it doesn't. It always seemed risky to use something like amiodarone or diltiazem, because they both stick around for a little while. Esmolol always made sense to me because of its short half-life and accuracy in terms of titrable heart rate control. I just never see it in anyone's guidelines except for thoracic aneurysms. In this paper from JAMA, septic patients were randomized to rate control with esmolol vs a control group receiving standard care. Check it out! Download the free PDF here: https://jamanetwork.com/journals/jama... www.foamfrat.com