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Early Implant Failure: Mechanical Problem or Immune Rejection?

Early implant failure remains one of the most frustrating complications in implant dentistry. Is it mechanical error — or immune-driven failure? In this video, Dr Stavros breaks down early implant failure through the lens of biology, osteoimmunology, angiogenesis, and immune response — explaining why torque values, drilling protocols, and implant brands alone cannot guarantee success. This is a must-watch for implant dentists, oral surgeons, and periodontists seeking predictable, biology-driven outcomes. CHAPTERS 00:00 Intro - Early implant failure — the uncomfortable question 00:57 What “Early Failure” really means 01:30 The ‘Bob the Builder' mindset 02:00 What We Blame (Mechanics) 02:38 The Immune System Decides 03:20 Titanium is Biocompatible - Not Biologically Silent 03:55 The Patient Factor We Ignore 04:22 Mid-video recap 04:40 Reframing the Question 05:06 Practical Clinical Reset (Wise, Biology-Informed Implantology) 05:39 Conclusion #DentalImplants #ImplantFailure #ImplantDentistry #Osseointegration #Osteoimmunology #BiologicImplantology #OralSurgery #ImplantComplications #BoneHealing #Angiogenesis #ImplantEducation #DentistryYouTube REFERENCES 1. Albrektsson T, et al. The long-term efficacy of currently used dental implants. Int J Oral Maxillofac Implants. 1986. 2. Davies JE. Understanding peri-implant endosseous healing. J Dent Educ. 2003. 3. Donath K, et al. Cellular reactions at the implant interface. Int J Oral Maxillofac Implants. 1992. 4. Trindade R, et al. Titanium particles and peri-implant bone loss. Acta Biomater. 2016. 5. Hotchkiss KM, et al. Titanium surface characteristics and immune response. Biomaterials. 2016. 6. Chen Z, et al. Osteoimmunomodulation in implant osseointegration. Biomaterials. 2018. 7. Kotsakis GA, et al. Implant surface immune response. Clin Oral Implants Res. 2014. 8. Shah FA, et al. Bone-implant interface biology. Acta Biomater. 2019. 9. Albrektsson T, et al. Foreign body reactions and osseointegration. Eur J Oral Implantol. 2017. 10. Ivanovski S, et al. Macrophage response in implant dentistry. Periodontology 2000. 2014. 11. Trindade R, et al. Corrosion and tribocorrosion of dental implants. J Dent Res. 2015. 12. Street J, et al. Vascular endothelial growth factor in bone repair. Bone. 2002. 13. Claes L, et al. Mechanical regulation of bone healing. Nat Rev Rheumatol. 2012. 14. Raghunathan VK, et al. Immune regulation of angiogenesis. Front Immunol. 2018. 15. Goodman SB, et al. Inflammatory responses to implant debris. J Orthop Res. 2013. 16. Li J, et al. Osteoimmunology: interaction of immune and skeletal systems. Clin Rev Allergy Immunol. 2015. 17. Botticelli D, et al. Healing at implants placed into fresh extraction sockets. Clin Oral Implants Res. 2004. 18. Esposito M, et al. Factors affecting implant failure. Cochrane Database Syst Rev. 2014. 19. Rakic M, et al. Early implant failure mechanisms. Clin Oral Investig. 2018. 20. Giannoudis PV, et al. Angiogenesis in fracture healing. Injury. 2007.