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In this video, Dr Sanjay Gupta, consultant cardiologist, discusses how cocaine use can effect the heart. Cocaine’s main effect is that it increases our sympathetic activity (flight or fight system) by increasing the amount of adrenaline, noradrenaline, dopamine and serotonin in the blood and therefore causing an exaggerated and prolonged activation of our sympathetic system. With regards to the heart, cocaine causes an increase in the heart rate and the blood pressure. Because it has the effect of narrowing the arteries, it can increase the narrowing in the heart arteries. This is also why the blood pressure goes up. What this means is that the user has a horrendous double whammy - the heart is made to ask for more blood and the blood flow is choked at the same time! Imagine trying to pressing down on the accelerator of your car with all the force that you can and blocking the pipe that takes the fuel to the engine at the same time. Imaging how damaging that is to the engine and how easily then engine can break down in that scenario. Another problem with this scenario is that it promotes stagnation of blood and therefore blood clots can form within the vessels which can then make everything worse. In this case, the heart can start suffocating as it does so it can go into funny heart rhythm disturbances which then make everything worse can prove fatal. In addition cocaine can also with interfere directly with the sodium and potassium channels in the heart and cause QT prolongation thereby predisposing patients to dangerous dysrhythmias. Disclaimer: The contents of this video do not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. Please consider subscribing to my youtube channel: YORKCARDIOLOGY A full transcript of this video will be available at drsanjayguptacardiologist.com You can participate in free live chats with me by joining my facebook page ‘@yorkcardiologist’ My instagram account is #YORKCARDIOLOGY My Whatsapp broadcasts are accessible by sending me a whatsapp message on 447951310008 To talk to me, visit www.yorkcardiology.co.uk Thank you to Ollie Cooper for his wonderful videography:-)