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Prognosis in cancer implies a calculated probability of an outcome. Numerous factors influence clinical outcomes including the tumour profile with its molecular characteristics, the anatomic disease extent, the patients’ characteristics with co-morbidities, treatment, and the social determinants of health. With key advances in cancer treatment and ever-increasing costs it is essential that we have the ability to accurately describe and calculate the probability of relevant outcomes in cancer. This is crucial to support global cancer control activities, deliver health-care services at lower costs, offer better quality and improve the patient experience of the health system. Through this Special Focus Dialogue, participants heard from experts about the value of cancer staging, use of prognosis and prognostic factors in cancer control planning, clinical practice, and research.