Topoisomerases: Life's Molecular Scissors, by Joe Deweese скачать в хорошем качестве

Topoisomerases: Life's Molecular Scissors, by Joe Deweese

Human cells have about six feet of DNA compacted into the tiny nucleus of each cell. This requires incredible compaction involving multiple loops and coils in the DNA. If expanded to just an inch in diameter, instead of only six feet, human DNA would be over 15,000 MILES long! Imagine having to deal with the tangles of such a cord. Topoisomerases are a group of protein enzymes that make temporary breaks in DNA and unknot and detangle the DNA before resealing those breaks. These fascinating molecular scissors work like no scissors we use. Without them, DNA would become hopelessly entangled and life would be impossible. They provide incredible evidence of biochemical foresight in living systems.