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Is there a real connection between bone marrow concentrate (BMC) cell counts and patient outcomes? Dr. Centeno tackles a common debate in regenerative orthopedics—whether colony-forming units (CFUs), total nucleated cell count (TNCC), and other stem cell metrics in BMC actually predict success. You'll learn how reduced stem cell presence correlates with various orthopedic conditions like non-unions and osteonecrosis, and how a higher MSC count has shown improved results across multiple studies—from rotator cuff repair to disc and fracture healing. Dr. Centeno explains why CFU and TNCC remain the most reliable indicators of dose and outcome in BMC therapies, despite newer but unproven metrics like growth factor or cytokine content. Dr. Centeno practices at the Centeno-Schultz Clinic and is one of the founders of interventional orthobiologics, with extensive research publications in the field. 🔔 If you find this content helpful, please like, comment, and subscribe to stay informed. / @centenohome To schedule a telemedicine or in-person visit, call +1-303-429-6448 or email us at [email protected]. Dr. Centeno also answers questions on his Reddit thread at / picl Join him for weekly Facebook Lives at / centenoschultzclinic to learn more. These Facebook Lives are also available in podcast format on: Apple: https://podcasts.apple.com/us/podcast... Amazon: https://music.amazon.com/podcasts/35d... Download Dr Centeno's book on craniocervical instability at https://centenoschultz.com/craniocerv... Join CCI Communities: PICL SubReddit: https://www.reddit.com/r/PICL/?rdt=58942 PICL Facebook Group: / ccjpicl Follow us for updates and news: Website: https://centenoschultz.com/ https://regenexx.com/ Facebook: / centenoschultzclinic Instagram: / centenoschultzclinic LinkedIn: / chris-centeno-m-d-b6838024 Centeno-Schultz Clinic 403 Summit Blvd Suite 201 Broomfield, CO 80021 303-429-6448 Key Timestamps: 00:00 – Do cell counts in BMC matter for outcomes? 01:02 – Key metrics: CFUs and TNCC explained 01:37 – No evidence for alternative metrics yet 02:28 – Low stem cell counts in orthopedic disease sites 02:56 – Studies linking higher CFUs to better healing