An Overview of Chemical Modifications to CRISPR RNA скачать в хорошем качестве

An Overview of Chemical Modifications to CRISPR RNA

CRISPR-based genome editing has emerged as an exciting technology for biomedical and therapeutic applications. Since 2015, a number of studies have explored the effects of chemically modifying the guide RNA components of CRISPR enzymes and the spectrum of modifications that are compatible. While primarily focused on improving editing efficiency or reducing off-target effects, these investigations have led to some important rules regarding the placement and type of modifications that may be used. This webinar will discuss the progress in this area of research and provide practical guidelines for chemically modifying CRISPR RNA.