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Hereditary Spherocytosis

Hereditary spherocytosis (HS) is the most prevalent cause of hemolytic anemia due to an abnormal red cell membrane and classifies as a type of congenital hemolytic anemia. Oskar Minkowsky first described it in the early 1900s. Erythrocytes are unable to maintain their normal biconcave shape due to genetic mutations in membrane/cytoskeletal proteins that play a role in structural morphologic stability. Deficient or abnormal proteins may include spectrin, ankyrin, band 3, and band 4.2, encoded by different genes. The clinical manifestations vary based on the severity of disease and the type of genetic mutation. Reference: Zamora EA, Schaefer CA. Hereditary Spherocytosis. [Updated 2020 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NB... Image credit: Kjpargeter, Stockking / Freepik @ http://www.freepik.com https://pngtree.com/so/vector https://pngtree.com/so/direction https://pngtree.com/so/blood clipart Murphree, S.. “A-PDF Split DEMO : Purchase from www.A-PDF.com to remove the watermark.” (2009). Tang, Yu-Hang & Lu, Lu & Li, He & Evangelinos, Constantinos & Grinberg, Leopold & Sachdeva, Vipin & Karniadakis, George. (2017). OpenRBC: A Fast Simulator of Red Blood Cells at Protein Resolution. Biophysical Journal. 112. 10.1016/j.bpj.2017.04.020. Das, Anirban & Bansal, Deepak. (2017). Non-immune Hemolytic anemia. hereditary spherocytosis, hereditary spherocytosis pathology, hereditary spherocytosis osmosis, hereditary spherocytosis anemia, hereditary spherocytosis pathology priyanka sachdev, hereditary spherocytosis usmle, hereditary spherocytosis dirty medicine, hereditary spherocytosis selfless medicose, hereditary spherocytosis شرح, hereditary spherocytosis pediatrics, hereditary spherocytosis and elliptocytosis, hereditary spherocytosis animation, hereditary spherocytosis uncovered a comprehensive guide pathology navigator dr, hereditary spherocytosis biochemistry, hereditary spherocytosis case presentation, hereditary spherocytosis dr najeeb, hereditary spherocytosis dr priyanka, osmotic fragility test hereditary spherocytosis, hereditary spherocytosis (hs), hereditary spherocytosis in hindi, hereditary spherocytosis pathology in hindi, hereditary spherocytosis in urdu, hereditary spherocytosis ilovepathology, what is hereditary spherocytosis, hereditary spherocytosis jj medicine, hereditary spherocytosis physiology, hereditary spherocytosis lecture, hereditary spherocytosis medicosis, hereditary spherocytosis malayalam, medicosis perfectionalis hereditary spherocytosis, hereditary spherocytosis ninja nerd, hereditary spherocytosis neet pg, hereditary spherocytosis pathology notes, pathogenesis of hereditary spherocytosis, pathophysiology of hereditary spherocytosis, hereditary spherocytosis pathophysiology, hereditary spherocytosis pathology unacademy, hereditary spherocytosis pathology osmosis, spherocytosis blood disorder, hereditary hemolytic anemia, hereditary spherocytosis treatment, hereditary spherocytosis unacademy, spherocytosis medicosis, spherocytosis osmosis, spherocytes in blood film, spherocytes