Is Your Mouse Model Telling You Only HALF the Story? скачать в хорошем качестве

Is Your Mouse Model Telling You Only HALF the Story?

With over 99% of AD clinical trials ending in failure, it's crucial to examine the foundational tools of our research. This video reveals a critical flaw in conventional mouse models: where on half of the tau isoform with mouse gene, standard models fail to recapitulate the complete disease pathology. Discover Cyagen's breakthrough HUGO-Tau™ model, a fully humanized mouse where the entire murine Mapt gene is replaced with the human genomic sequence. This allows for the expression of all six human tau isoforms (3R and 4R), providing a more clinically relevant and predictive platform for studying tauopathies and developing next-generation discovery, as well as supporting basic research. 🔬 Advance your research with a complete, human-relevant tau model. ▶️ Watch our in-depth webinar on the HUGO-Tau™ model's design and validation:    • Humanized Tauopathy in HUGO Mouse Models: ...   💡 Accelerate your Alzheimer's disease research & drug development: https://www.cyagen.com/cro-services/n... #AlzheimersResearch #Neuroscience #MouseModel #Tauopathy #DrugDiscovery #Cyagen