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They are small growths which happen on the sides of the glans penis and these are actually small growths and cannot be removed by some creams or solutions. Ideally they need to be destroyed. It is like how we destroy a skin tag, or a molluscum, or a viral wart. So basically, the safest thing that I would prefer is to take it out under local anesthesia. There are a lot of contact irritants when applied cause some damage to this pearly penile papules, but they give irritation reaction, then but they may also give damage to the pearly penile papules. They may also cause irritation to the genitals or can give permanent scarring. So I would not advise you to use these irritant creams in pearly penile papules, looking at the damage which can cause you. The safest modality is getting it rid with radiofrequency or laser. These papules are a physiological growth and if you leave it and it is, it is more like a concern which is uncosmetic. Rather than that it can rarely cause any harm or does not signal any malignancy.