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I describe the Total Synthesis of Hunterine A, a natural product that features a 6/7/6/6/5 pentacyclic skeleton. The molecule can be isolated from the leaves of Hunteria Zeylanica, a plant that has been used in traditional Chinese medicine to treat skin irritations. Some of the key steps in the synthesis of this molecule involve: 1. Formation of the seven-membered azepane motif through an azide-olefin cycloaddition. 2. Preparation of the quaternary center via an aza-Cope/Mannich rearrangement from a bicyclic alcohol. 3. A diastereoselective 1,2-addition of a vinyl species to a ketone to generate the bicyclic alcohol. 4. Formation of a bicyclic ketone from a desymmetrization and a Beckmann rearrangement of a symmetrical bicyclic diketone. Named Reactions: Cope rearrangement: https://nrochemistry.com/cope-rearran... Mannich reaction: https://nrochemistry.com/mannich-reac... Beckmann rearrangement: The Chemists' Cookbook: https://nrochemistry.com/the-chemists... This essential reference book arranges reactions alphabetically and by type, highlighting target molecules, reaction conditions, isomer ratios, reported yields, references to source articles, and experimental procedures. Additional notes discuss the practical scope and utility of each reaction, covering modifications, intermediate structures, and, in some cases, reaction mechanisms. These entries not only demonstrate the chemistry involved but also clarify its real-world applications, making it an invaluable resource for chemists at every level. The Chemists' Cookbook includes an introduction by Professor Erick Carreira and a foreword by Professor Phil Baran, underscoring its significance to the field of synthetic organic chemistry. References: Introduction: 1. J. Am. Chem. Soc. 2024, 146, 7, 4340–4345. https://doi.org/10.1021/jacs.3c13590 2. J. Org. Chem. 2019, 84, 22, 14892–14897. https://doi.org/10.1021/acs.joc.9b01835 For the umpolung ylide addition : 1. Tetrahedron Lett. 1988, 29, 5413–5416. https://doi.org/10.1016/S0040-4039(00... For the conjugate addition: 1. Posner, G.H. (2011). Conjugate Addition Reactions of Organocopper Reagents. In Organic Reactions, (Ed.). https://doi.org/10.1002/0471264180.or... 2. Chem. Rev. 2012, 112, 4, 2339–2372. https://doi.org/10.1021/cr200241f Amazon.com: https://a.co/d/7LAj0HR The Chemists’ Cookbook paperback is available for purchase on the following Amazon’s marketplaces: US, UK, CA, DE, FR, ES, IT, NL, PL, and SE. Please check your nearest marketplace to verify whether a delivery to your country is possible.