У нас вы можете посмотреть бесплатно Thyroid Cancers или скачать в максимальном доступном качестве, видео которое было загружено на ютуб. Для загрузки выберите вариант из формы ниже:
Если кнопки скачивания не
загрузились
НАЖМИТЕ ЗДЕСЬ или обновите страницу
Если возникают проблемы со скачиванием видео, пожалуйста напишите в поддержку по адресу внизу
страницы.
Спасибо за использование сервиса ClipSaver.ru
This is a video on the most common cancers that originate in the thyroid tissue. I created this presentation with Google Slides. Image were created or taken from Wikimedia Commons I created this video with the YouTube Video Editor. ADDITIONAL TAGS: Thyroid cancers The most common carcinomas that originate in the thyroid tissue Epi: Frequency of 80 percent (most common); good prognosis (10 year survival 95%); F:M 3:1; peak incidence in 30s to 50s Gross: irregular contours, no capsule around it Histo: nuclear clearing (nuclei appear empty - “Orphan Annie eye†), nuclear grooves, intranuclear pseudoinclusions, psammoma bodies (calcifications) , reduced colloid, crowded cells, papillary architecture (sometimes present) Derived from follicular cells Increased risk: mutations (RET and BRAF), radiation exposure as child Spread: often by lymphatic invasion to cervical nodes, neck; slow growth Secretes thyroglobulin; takes up radioiodine Treat: lobectomy (maybe total thyroidectomy with lymph node removal) High risk pts get radioiodine tx TSH suppression with thyroid hormone replacement Epi: Frequency of 10 percent; more aggressive than papillary with early metastases; also F:M 3:1; peak in 40s to 60s Histo: monotonous/uniform population, overlapping follicular cells, microacinar formation, reduced colloid, might contain Hurthle cells Derived from follicular cells Increased risk: mutations in RAS Spread: often by vascular invasion; locally invasive, invades thyroid capsule Distal spread more common than papillary Invades blood vessels and invades through the capsule Differentiate from follicular adenoma: Secretes thyroglobulin; takes up radioiodine (except Hurthle cells) Same treatment: lobectomy (maybe total thyroidectomy with lymph node removal) High risk pts get radioiodine tx TSH suppression with thyroid hormone replacement Epi: Frequency of 5%; more aggressive than follicular with early metastases; Sporadic (80%) → F:M 3:2, peak in 40s to 60s Familial (20%) → F:M 1:1, peak onset at early age Histo: neuroendocrine appearance, ‘packets’ of uniform cells; stroma made of amyloid (stains w Congo red) Derived from parafollicular cells (C (clear) cells); produces calcitonin Increased risk: family with MEN 2A and 2B (association), mutation in RET (proto-oncogene) Spread: early metastases Does not secrete thyroglobulin; does not take up radioiodine Same treatment: lobectomy (maybe total thyroidectomy w lymph node removal) Thyroid hormone replacement for normal TSH (no TSH suppression) Anaplastic carcinoma Left of image is amyloid, right of image is near normal thyroid follicles Anaplastic carcinoma AKA undifferentiated carcinoma (because it’s poorly differentiated) Epi: Frequency of 3 percent; very aggressive, poor prognosis, most deadly; M:F 2:1, peak in 60s to 80s Histo: several variants, but all high grade Spread: infiltrative into local structures, soft tissue of neck; widespread metastases, early mortality Does not take up radioiodine Papillary carcinoma Follicular carcinoma Medullary carcinoma Anaplastic carcinoma