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Precision Approaches to Pancreatic Cancer: From Oncology to Surgery

This webinar covered the latest advances in the treatment and care of pancreatic cancer, one of the most challenging malignancies worldwide. It brought together leading oncologists from India and the U.S. to discuss precision therapies, surgical innovations, and evolving radiotherapy approaches to improve patient outcomes. Columbia HICCC Cancer Series is organized by the Columbia Global Center Mumbai in partnership with Columbia University's Herbert Irving Comprehensive Cancer Center (HICCC) and with the support of Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Rajiv Gandhi Cancer Institute & Research Centre (RGCIRC), Max Healthcare, Jupiter Hospital and Tata 1 mg. 0:00 – Introduction & Opening Remarks 0:30 – Progress in Chemotherapy & Precision Medicine 2:10 – Targeting KRAS Mutations in Pancreatic Cancer 6:30 – Pan-KRAS Inhibitors & Emerging Therapies 10:00 – Immunotherapy: Challenges & New Approaches 12:30 – mRNA Vaccines & Personalized Treatment 15:00 – Targeting the Tumor Microenvironment 19:30 – Radiotherapy: From Conventional to Ablative 29:00 – Key Clinical Trials & Evidence to Date 41:30 – Radiotherapy for Pain Control 44:00 – Case Studies: Radiotherapy + Chemotherapy Before Surgery 45:50 – Institutional Experience & Outcomes in Locally Advanced Disease 47:00 – Introduction to the Role of Surgery in Borderline & Locally Advanced Cancers 48:00 – Evolution of Pancreatic Surgery: Safer & More Radical Approaches 50:00 – Treatment Planning: Anatomy, Biomarkers & Performance Status 52:00 – Evidence from Trials: Neoadjuvant Therapy & R0 Resection Rates 54:45 – Conversion Surgery in Locally Advanced Pancreatic Cancer 56:30 – Surgical Techniques: Artery-First, Vein & Arterial Resections 1:02:50 – Divestment Procedures & Expanding Surgical Feasibility 1:05:50 – Outcomes, Survival Data & Institutional Experience 1:09:00 – Summary: Biology, Patient Selection & Dynamic Definitions 1:11:00 – Panel Q&A: Biomarkers, NGS & Treatment Approaches 1:19:00 – Practical Questions: SBRT, Fiducials & CyberKnife vs IGRT 1:21:05 – Final Thanks & Closing of Webinar   / columbia.global     / columbiaglobal   https://global.columbia.edu/