Single-cell mapping of human brain cancer reveals tumor-driven education of tumor-associated leuk... скачать в хорошем качестве

Single-cell mapping of human brain cancer reveals tumor-driven education of tumor-associated leuk...

Presented By: Burkhard Becher, PhD Speaker Biography: Burkhard Becher studied Biology at the University of Cologne in Germany and specialized in Molecular Genetics and Biochemistry. In 1995, for his graduate studies he went to the Montreal Neurological Inst. at McGill University in Canada to train in Neuroimmunology with Jack Antel. Webinar: Single-cell mapping of human brain cancer reveals tumor-driven education of tumor-associated leukocytes Webinar Abstract: Brain malignancies can either originate from within the CNS (gliomas) or invade from other locations in the body (metastases). A highly immunosuppressive tumor microenvironment (TME) influences brain tumor outgrowth. Whether the TME is predominantly shaped by the CNS micromilieu or by the malignancy itself is unknown, as is the diversity, origin, and function of CNS tumor-associated macrophages (TAMs). Here, we have mapped the leukocyte landscape of brain tumors using high-dimensional single-cell profiling (Cy- TOF).