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What’s Hot at ACC.26: in this focused preview, Dr Azeem Latib and Prof Nicolas Van Mieghem, MD, PhD, pick out the late‑breaking clinical trials at ACC.26 that are most likely to influence practice for operators heading to New Orleans. In a fast, conversational format, they move from pulmonary embolism and left atrial appendage closure to heart failure, STEMI unloading, high‑risk PCI, and cerebral protection in TAVI, always coming back to what the designs, endpoints, and safety signals could mean for day‑to‑day decision‑making in the cath lab and structural heart program. Produced by Radcliffe Cardiology, this ACC.26 late‑breaking clinical trials preview gives busy interventional and structural cardiologists a clear, opinion‑driven guide to the key data to watch; while our chaptered sections on the page let you dive deeper into each trial area as needed, and set the stage for our on‑site coverage from ACC.26. Videographer: Mike Knight Editor: Mirjam Boros Visit Radcliffe Cardiology: https://www.radcliffecardiology.com/ This content is intended for healthcare professionals only. Radcliffe brings medical knowledge, insight and innovation to life for CV clinicians around the world, using our communications & creative expertise, our platforms and connections across the community to help transform theory into practice faster. Like us on Facebook: / radcliffecardiology Follow us on X: https://x.com/radcliffeCARDIO