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Stevia is a sweetener and sugar substitute derived from the leaves of the plant species Stevia rebaudiana , native to Brazil and Paraguay . Steviol , the basic building block of stevia's sweet glycosides The active compounds are steviol glycosides (mainly stevioside and rebaudioside ), which have 30 to 150 times the sweetness of sugar, [3] are heat-stable, pH -stable, and not fermentable . [4] The body does not metabolize the glycosides in stevia, so it contains zero calories, like some artificial sweeteners . Stevia's taste has a slower onset and longer duration than that of sugar, and some of its extracts may have a bitter or licorice -like aftertaste at high concentrations. The legal status of stevia as a food additive or dietary supplement varies from country to country. In the United States , high-purity stevia glycoside extracts have been generally recognized as safe (GRAS) since 2008, and are allowed in food products, but stevia leaf and crude extracts do not have GRAS or Food and Drug Administration (FDA) approval for use in food. [5] The European Union approved Stevia additives in 2011, [6] while in Japan , stevia has been widely used as a sweetener for decades. History Discovery Stevia rebaudiana The plant Stevia rebaudiana has been used for more than 1,500 years by the Guaraní peoples of South America, who called it ka'a he'ê ("sweet herb"). [8] The leaves have been used traditionally for hundreds of years in both Brazil and Paraguay to sweeten local teas and medicines, and as a "sweet treat". [8] The genus was named for the Spanish botanist and physician Petrus Jacobus Stevus. [a] In 1899, Swiss botanist Moisés Santiago Bertoni , while conducting research in eastern Paraguay, first described the plant and the sweet taste in detail. [10] Only limited research was conducted on the topic until, in 1931, two French chemists isolated the glycosides that give stevia its sweet taste. [11] Early regulation During the 1990s, the United States Food and Drug Administration (FDA) received two petitions requesting that stevia be classified as generally recognized as safe (GRAS), but the FDA "disagreed with [the] conclusions [detailed in the petitions]". [12] Stevia remained banned for all uses until the Dietary Supplement Health and Education Act of 1994 , after which the FDA revised its stance and permitted stevia to be used as a dietary supplement , although still not as a food additive. [13] In 1999, prompted by early studies, the European Commission banned stevia's use in food products within the European Union pending further research. [14] In 2006, research data compiled in the safety evaluation released by the World Health Organization found no adverse effects. [15] In December 2008, the FDA gave a "no objection" approval for GRAS status to Truvia [b] and PureVia , [c] both of which use rebaudioside A derived from the Stevia plant. [16] However, the FDA said that these products are not stevia, but a highly purified Stevia -extract product. [17] In 2015, the FDA still regarded stevia as "not an approved food additive", and stated that it "has not been affirmed as GRAS in the United States due to inadequate toxicological information". [18] In June 2016, the U.S. Customs and Border Protection issued an order of detention for stevia products made in China based on information that the products were made using prison labor . [19] As of 2017, high-purity Stevia glycosides are considered safe and allowable as ingredients in food products sold in the United