Causes, epidemiology and risk factors of celiac disease: Celiac disease lecture 4 скачать в хорошем качестве

Causes, epidemiology and risk factors of celiac disease: Celiac disease lecture 4

Causes Coeliac disease is caused by a reaction to gluten i.e gliadins and glutenins. Sometimes celiac disease is triggered — or becomes active for the first time — after surgery, pregnancy, childbirth, and viral infection or severe emotional stress. 1. Type 1 diabetes 2. Thyroid conditions 3. Ulcerative colitis – a digestive condition that causes inflammation of the colon (large bowel) 4. Neurological disorders (which affect the brain and nervous system) such as epilepsy 5. Down's syndrome and Turner syndrome Epidemiology Globally coeliac diseases affect between 1 in 100 and 1 in 170 people. Due to variable signs and symptoms it is believed that about 85% of people affected are undiagnosed and only 1-2% people can be diagnosed. Mechanisms of action in body or pathogenesis Upon exposure to gluten, an abnormal immune response may lead to the production of several different autoantibodies that can affect a number of different organ she disease is began when we take gluten food. During this disease when glaiden is reach to bowel area then many antibodies are released against it and react with it. After that the lymphocytes and some other WBC are released in a large number and the war is going on and finally the inflammation occur in the small intestine and the wall of small intestine is damaged. As the wall of small intestine is responsible for absorption so the absorption will be disrupted. Thus the following compound or molecules are not absorb 1. Water that can lead to diarrhea 2. Fats that can lead to steatorrhea 3. Iron and vit B12 that can lead anemia Risk factor The eating of gluten early in a baby's life does not appear to increase the risk of CD but later introduction after 6 months may increase it. Coeliac disease leads to an increased risk of both adenocarcinoma and lymphoma of the small bowel. Long-standing and untreated disease may lead to other complications, such as ulcerative jejunitis (ulcer formation of the small bowel) and stricturing (narrowing as a result of scarring with obstruction of the bowel). Pregnancy complications including miscarriage, intrauterine growth restriction, low birth weight and preterm birth. Reduction of risk factor Breastfeeding Prolonging breastfeeding until the introduction of gluten-containing grains into the diet appears to be associated with a 50% reduced risk of developing coeliac disease in infancy