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Pilocarpine, a muscarinic receptor agonist, has several clinical applications and uses, including: 1. Glaucoma: Pilocarpine is used to treat glaucoma, reducing intraocular pressure by increasing aqueous humor outflow. 2. Dry mouth (xerostomia): Pilocarpine stimulates salivary glands, helping treat dry mouth in patients with Sjögren's syndrome or radiation-induced xerostomia. 3. Urinary retention: Pilocarpine helps treat urinary retention by stimulating the bladder detrusor muscle. 4. Bronchospasm: Pilocarpine's muscarinic agonist properties help relieve bronchospasm in asthma and COPD. 5. Gastrointestinal disorders: Pilocarpine stimulates intestinal muscle contractions, helping treat constipation. 6. Sweating disorders: Pilocarpine is used to treat hypohidrosis (reduced sweating) and hyperhidrosis (excessive sweating). 7. Ophthalmic procedures: Pilocarpine is used during ophthalmic surgeries like cataract extraction and intraocular lens implantation. 8. Diagnostic tool: Pilocarpine is used in diagnostic tests like the pilocarpine sweat test for cystic fibrosis. 9. Treatment of poisoning: Pilocarpine can be used as an antidote for certain poisonings, like organophosphate poisoning. It's important to note that Pilocarpine should only be used under medical supervision, as it can have adverse effects like muscle weakness, sweating, and increased salivation. #Pilocarpine