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POEMS syndrome (Polyneuropathy Organomegaly, Endocrinopathy, M-protein and Skin changes) is rare, and systemic manifestations are commonly overlooked initially. Diagnosis is often delayed 12-16 months, during which patients can be severely disabled. No established treatment guidelines exist for POEMS. A recent HemaSphere (https://onlinelibrary.wiley.com/journ...) published article, Comprehensive Diagnosis and Management of POEMS Syndrome (https://onlinelibrary.wiley.com/doi/1...) , offers a clinical blueprint for managing POEMS, from diagnostics to work-up, therapy selection, follow-up, and relapse treatment. Shirley d'Sa & Michael Lunn, two co-authors of the article discuss with host Dr Stephen Hibbs, in this first of 2 episodes, why multidisciplinary collaboration is essential. Continue with Part 2 here (https://hemasphere-podcast.captivate....) . This podcast is also available on YouTube: Part 1 ( • Part 1 - Comprehensive Diagnosis and Manag... ) and Part 2 ( • Comprehensive Diagnosis and Management of ... )