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The National One Health Mission (NOHM) is a crucial Indian initiative for integrated disease control and pandemic preparedness, linking human, animal (livestock/wildlife), plant, and environmental health, approved by PM-STIAC in 2022, anchored by ICMR, and focuses on coordinated surveillance, R&D for tools (vaccines, diagnostics), and building robust outbreak response systems, relevant for UPSC's social justice and health topics. It addresses zoonotic threats like COVID-19, Nipah, and Avian Influenza, institutionalizing a holistic approach through multi-sectoral coordination. Key Aspects for UPSC: Concept: Recognizes the interconnectedness of health across humans, animals, and the environment for holistic well-being. Objective: Create integrated surveillance, early warning, and response systems for diseases affecting humans, animals, and the environment. Approval & Anchoring: Approved by PM-STIAC (2022); anchored by ICMR under the Office of the Principal Scientific Adviser (PSA). Pillars: Integrated surveillance (human, animal, environment), R&D (tools), robust outbreak investigation, clinical care, data sharing, and community participation. Relevance: Essential for addressing zoonotic diseases (like COVID-19, Nipah), improving biodiversity, and achieving global health security. Institutionalization: Brings together multiple ministries (Health, Animal Husbandry, Environment, DST, DBT, etc.) for coordinated action.