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Dr. Shalabh Gupta is the founder of Unicycive, a biotech company working to simplify treatment for dialysis patients. He’s also a physician, former Genentech executive, and someone who thinks deeply about careers, leadership, and the role of AI in healthcare. In this episode, we cover the problem of pill burden, how to reverse engineer your career, and what most people misunderstand about medical education. Inside This Episode with Dr. Shalabh Gupta: The hidden disconnect in medical education—and how to fix it How reverse engineering your goals can reshape your career What Dr. Shalabh Gupta learned from Genentech leaders before taking the leap The true cost of pill burden—and how Unicycive aims to change that How AI is already improving medicine What it takes to bring a drug to market Why mentorship sharpens your own path Chapters: 00:49 – Medical background and training path 02:20 – Education system gaps in career planning 05:12 – Asking students where they want to be next year 08:20 – Faculty saying they wouldn’t do it again 12:23 – Talking to physicians before choosing medicine 16:26 – Internal compass and leaving Genentech 21:46 – Building resilience and taking calculated risks 25:57 – Learning through mentoring others 30:46 – AI as augmentation in healthcare 37:39 – What physicians actually want to do for patients 42:24 – Healthcare system disconnect and access problems 45:47 – Staying focused on controllable factors 48:40 – Pill burden problem for dialysis patients 52:58 – FDA approval and commercialization plans 57:45 – Multiple career paths and staying curious 59:00 – Final advice on asking questions and seeking knowledge Dr. Shalabh Gupta & Unicycive Unicycive: https://unicycive.com/ Dr. Shalabh Gupta on LinkedIn: / shalabhgupta Dr. Gupta’s personal website: https://www.shalabhguptamd.com/ Related episodes: Ankit Somani | Google Rare-Earth-Free Motors, $20M Seed, Rethinking College: • Ankit Somani | From Google to Conifer: Rar... Remote Work in Today’s Financial Advisory Industry | Joe Cantanucci: • EP184 | Remote Work in Today’s Financial A... The Future of Customer Engagement with Mike Donohue: • EP 176 | The Future of Customer Engagement... Entrepreneur Perspectives is produced by QuietLoud Studios — a modern media network and a KazSource brand. https://quietloudstudios.com/ Get in touch with Eric Kasimov: https://x.com/eric_kaz / erickasimov